Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion.

نویسندگان

  • S M Karim
  • D C Carter
  • D Bhana
  • P A Ganesan
چکیده

The effect of orally administered prostaglandin E(2) and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E(2) compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E(2) methyl ester and its isomer, 15 (R) 15-methyl-E(2) methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.

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عنوان ژورنال:
  • British medical journal

دوره 1 5846  شماره 

صفحات  -

تاریخ انتشار 1973